Edema, Leg Edema and OPC

“Italian scientists from the University of Florence studied the effect of OPC’s on venous congestion in the legs – leg edema. The study involved 40 subjects consisting of 13 men and 27 women between the ages of 34 and 74, having an average age of 60 years. The subjects were randomly divided into two groups. One group served as the control group and received a placebo supplement that appeared identical to the OPC supplement but contained an inactive substance. The other group received 300 milligrams of OPC daily for 60 days.

“All of those taking the OPC had relief from at least some of the symptoms. There was a decrease in the feeling of heaviness in lower limbs in 11 percent of those receiving OPC after 30 days, and in 33 percent after 60 days.

“The swelling disappeared in 26 percent of those taking the OPC’s after 30 days, and in 63 percent after 60 days (circumference measured above the ankle before and after test). Pain in the lower limbs was totally relieved in 38 percent of those taking OPC’s after 30 days, and in 67 percent after 60 days.”

“Veins are fairly frail structures. Defects in the wall of a vein lead to dilation of the vein and damage to the valves. When the valves become damaged, the increased static pressure results in the bulging veins known as varicose veins.” (Encyclopedia of Natural Medicine, by Michael Murray, N.D. and Joseph Pizzorno, N.D., 1991).


Capillary problems manifest themselves as a series of symptoms resulting from poor circulation in the legs. This complex of symptoms is classified as varicose veins….we find that people complain about these functional problems such as: pain, swelling, itching, restlessness and cramps which, in many cases, also can cause insomnia. All these functional problems, as we shall see, are favorably influenced by OPC.

Venous insufficiency was tested (1985) on ninety-two patients who were administered 300mg of OPC per day. Also here it concerned functional disorders such as “heavy legs,” “itching,” “nighttime cramps,” and edema. After using OPC for four weeks, the treatment appeared to be successful for 75% of the patients.


“OPC’s main claim to fame is it’s unique ability to strengthen the walls of blood vessels weakened by age and disease. OPC thus reverses the fragility of blood vessels, making them more intact and supple so blood flows through easily and doesn’t leak out. OPC accomplishes this by actually creating tougher, thicker, more tightly knit blood vessel walls that are less likely to stretch, leak, or burst. As Dr. Masquelier explains, two proteins in the vessel wall, collagen and elastin, greatly determine the elasticity and permeability of the vascular wall, whether the wall is solid, strong, and flexible, or fragile and leaky. OPC attaches to these two building block proteins, preventing their degradation by destructive enzymes and encouraging their synthesis and maturation. In short, OPC reinforces the structure of the connective tissue that makes blood vessels strong and resistant.” (Miracle Cures, by Jean Carper)

That’s why OPC is, you could say, the vitamin of the vascular wall. ” (OPC in Practice, by Bert Schwitters in Collaboration with Prof. Jack Masquelier)

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